Gene information
Official symbol CHRNB2
Official full name cholinergic receptor nicotinic beta 2 subunit
Gene type protein-coding gene
Chromosome1q21.3
Gene familyCholinergic receptors nicotinic subunits
Resources
Entrez Gene 1141
HGNC HGNC:1962
Ensembl ENSG00000160716
Vega OTTHUMG00000037262
UCSC uc001ffg.4
GO terms: 96 records
GO Description Category LogP Number of genes Detail
GO:0000902 cell morphogenesis GO Biological Processes -11.5134430 38 More
GO:0000904 cell morphogenesis involved in differentiation GO Biological Processes -8.70147397 29 More
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0003012 muscle system process GO Biological Processes -27.3938503 63 More
GO:0003014 renal system process GO Biological Processes -10.4348518 24 More
GO:0005261 cation channel activity GO Molecular Functions -1.68739377 23 More
GO:0006816 calcium ion transport GO Biological Processes -5.55009887 27 More
GO:0006939 smooth muscle contraction GO Biological Processes -6.47455620 13 More
GO:0007268 chemical synaptic transmission GO Biological Processes -4.44678751 35 More
GO:0007409 axonogenesis GO Biological Processes -2.66639313 13 More
GO:0007420 brain development GO Biological Processes -11.5572036 75 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0007611 learning or memory GO Biological Processes -7.55755517 33 More
GO:0007612 learning GO Biological Processes -4.32260958 18 More
GO:0007613 memory GO Biological Processes -4.31484432 16 More
GO:0007626 locomotory behavior GO Biological Processes -5.45844211 23 More
GO:0008306 associative learning GO Biological Processes -3.80327331 12 More
GO:0010975 regulation of neuron projection development GO Biological Processes -5.89330331 41 More
GO:0015267 channel activity GO Molecular Functions -2.12225487 15 More
GO:0015318 inorganic molecular entity transmembrane transporter activity GO Molecular Functions -2.11605072 20 More
GO:0019233 sensory perception of pain GO Biological Processes -10.7642352 20 More
GO:0021536 diencephalon development GO Biological Processes -4.93822812 13 More
GO:0021675 nerve development GO Biological Processes -3.85527067 12 More
GO:0021953 central nervous system neuron differentiation GO Biological Processes -5.15897962 21 More
GO:0022803 passive transmembrane transporter activity GO Molecular Functions -2.11455525 15 More
GO:0030534 adult behavior GO Biological Processes -6.59104580 21 More
GO:0030900 forebrain development GO Biological Processes -11.1545964 48 More
GO:0031175 neuron projection development GO Biological Processes -7.36986002 58 More
GO:0031344 regulation of cell projection organization GO Biological Processes -8.91314416 62 More
GO:0032989 cellular component morphogenesis GO Biological Processes -4.92421328 47 More
GO:0032990 cell part morphogenesis GO Biological Processes -4.32681114 20 More
GO:0033238 regulation of cellular amine metabolic process GO Biological Processes -3.34516618 7 More
GO:0033605 positive regulation of catecholamine secretion GO Biological Processes -3.89921208 5 More
GO:0035094 response to nicotine GO Biological Processes -8.07167727 14 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0042391 regulation of membrane potential GO Biological Processes -15.0641346 59 More
GO:0042734 presynaptic membrane GO Cellular Components -4.19875640 10 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043279 response to alkaloid GO Biological Processes -4.89883771 15 More
GO:0044853 plasma membrane raft GO Cellular Components -18.4542052 33 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045211 postsynaptic membrane GO Cellular Components -5.83105498 30 More
GO:0048667 cell morphogenesis involved in neuron differentiation GO Biological Processes -4.77475952 19 More
GO:0048812 neuron projection morphogenesis GO Biological Processes -4.67859800 20 More
GO:0048858 cell projection morphogenesis GO Biological Processes -4.57120185 20 More
GO:0050433 regulation of catecholamine secretion GO Biological Processes -6.37680507 13 More
GO:0050773 regulation of dendrite development GO Biological Processes -1.77380598 5 More
GO:0050795 regulation of behavior GO Biological Processes -5.81792293 14 More
GO:0050803 regulation of synapse structure or activity GO Biological Processes -6.38009123 27 More
GO:0050804 modulation of chemical synaptic transmission GO Biological Processes -15.2260557 60 More
GO:0050807 regulation of synapse organization GO Biological Processes -6.08931613 26 More
GO:0050890 cognition GO Biological Processes -8.00500082 37 More
GO:0050954 sensory perception of mechanical stimulus GO Biological Processes -4.15913068 20 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051047 positive regulation of secretion GO Biological Processes -32.2282376 71 More
GO:0051899 membrane depolarization GO Biological Processes -3.15848951 8 More
GO:0051952 regulation of amine transport GO Biological Processes -10.5179624 22 More
GO:0051954 positive regulation of amine transport GO Biological Processes -5.35296451 10 More
GO:0051963 regulation of synapse assembly GO Biological Processes -2.88690436 12 More
GO:0060078 regulation of postsynaptic membrane potential GO Biological Processes -2.74505261 11 More
GO:0060322 head development GO Biological Processes -11.995356 79 More
GO:0061564 axon development GO Biological Processes -3.13387450 15 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0095500 acetylcholine receptor signaling pathway GO Biological Processes -3.70345918 7 More
GO:0097060 synaptic membrane GO Cellular Components -5.94418548 20 More
GO:0097305 response to alcohol GO Biological Processes -17.4096682 46 More
GO:0098793 presynapse GO Cellular Components -4.56552653 42 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0098889 intrinsic component of presynaptic membrane GO Cellular Components -4.93822812 13 More
GO:0098900 regulation of action potential GO Biological Processes -5.92071483 13 More
GO:0098916 anterograde trans-synaptic signaling GO Biological Processes -4.44678751 35 More
GO:0098926 postsynaptic signal transduction GO Biological Processes -3.73790071 8 More
GO:0098936 intrinsic component of postsynaptic membrane GO Cellular Components -4.76116234 10 More
GO:0098948 intrinsic component of postsynaptic specialization membrane GO Cellular Components -4.56568042 8 More
GO:0098960 postsynaptic neurotransmitter receptor activity GO Molecular Functions -2.86473787 9 More
GO:0098981 cholinergic synapse GO Cellular Components -3.57943474 3 More
GO:0099055 integral component of postsynaptic membrane GO Cellular Components -4.91964814 10 More
GO:0099056 integral component of presynaptic membrane GO Cellular Components -4.69230219 12 More
GO:0099060 integral component of postsynaptic specialization membrane GO Cellular Components -4.68780123 8 More
GO:0099177 regulation of trans-synaptic signaling GO Biological Processes -15.1793607 60 More
GO:0099240 intrinsic component of synaptic membrane GO Cellular Components -5.23284212 12 More
GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential GO Molecular Functions -3.0845403 5 More
GO:0099536 synaptic signaling GO Biological Processes -6.00976162 42 More
GO:0099537 trans-synaptic signaling GO Biological Processes -5.17038357 38 More
GO:0099572 postsynaptic specialization GO Cellular Components -2.67743186 13 More
GO:0099634 postsynaptic specialization membrane GO Cellular Components -4.18233935 9 More
GO:0099699 integral component of synaptic membrane GO Cellular Components -4.78109966 11 More
GO:0120035 regulation of plasma membrane bounded cell projection organization GO Biological Processes -8.54789693 60 More
GO:0120039 plasma membrane bounded cell projection morphogenesis GO Biological Processes -4.62455556 20 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1901888 regulation of cell junction assembly GO Biological Processes -8.71146171 30 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903532 positive regulation of secretion by cell GO Biological Processes -27.9542102 63 More
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling GO Biological Processes -7.80587066 38 More
GO:1905144 response to acetylcholine GO Biological Processes -4.09043632 8 More
GO:1905145 cellular response to acetylcholine GO Biological Processes -3.51698265 7 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
hsa05207 Chemical carcinogenesis - receptor activation KEGG Pathway -7.05448873 28 More
Drug-Gene interaction
view
Related drugs: 16 records
Drug name Interaction type Source PMID View
abt-560 modulator ChemblInteractions view
altinicline agonist ChemblInteractions view
azd1446 agonist ChemblInteractions view
cp-601927 partial agonist ChemblInteractions view
cytisinicline partial agonist TTD 20331614 view
dexmecamylamine antagonist TdgClinicalTrialChemblInteractionsTTD view
ispronicline partial agonist TdgClinicalTrialChemblInteractions view
nicotine agonist DTCTdgClinicalTrialChemblInteractionsTENDPharmGKB 1663679120854418195600481722679811006350261648422040046920081230 view
nicotine polacrilex agonist ChemblInteractions view
pozanicline partial agonist TdgClinicalTrialChemblInteractions view
sofinicline agonist ChemblInteractions view
tc-2216 antagonist ChemblInteractions view
tc-6499 agonist TdgClinicalTrialChemblInteractions view
tebanicline agonist ChemblInteractions view
varenicline partial agonist TdgClinicalTrial 16883648 view
varenicline tartrate agonist ChemblInteractions view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
cg00818872 hypermethylation epigenomics myocardial infarction[diagnosis] myocardial infarction Rask-Andersen M et al. Hum Mol Genet. 2016
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